Nigericin, monosodium salt
Nigericin sodium salt
CAS: 28643-80-3
Molecular Formula: C40H69NaO11
Nigericin, monosodium salt - Names and Identifiers
Nigericin, monosodium salt - Physico-chemical Properties
| Molecular Formula | C40H69NaO11 |
| Molar Mass | 748.97 |
| Melting Point | approximate 255℃ |
| Boling Point | 779.9°Cat760mmHg |
| Solubility | chloroform: soluble;ethanol: soluble;ethyl acetate: soluble |
| Appearance | White to white-like solid |
| Color | White |
| Merck | 13,6569 |
| BRN | 3892398 |
| Storage Condition | 2-8°C |
| Stability | Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 2 months. |
| MDL | MFCD00036825 |
| In vitro study | Nigericin (0.1 µM) decreases inhibits proliferation and clonogenicity of H460 lung cancer cells in a dose dependent manner. Nigericin inhibits migration and invasion of H460 lung cancer cells. Nigericin (0.1-10 nM) has apparently a dual effect on cell volume, that is a shrinking effect at lower Nigericin concentrations and a swelling effect at higher concentrations. Nigericin (0.1-1 nM) significantly decreases cytosolic pH (pHi), and slightly increases the pHi at 5 and 10 nM. Nigericin exhibits higher toxicity on S18 cells than S26 cells, with IC 50 of 2.03±0.55 μM and 4.77±2.35 μM, respectively. Nigericin can selectively kill cancer stem cells in NPC in vitro. Nigericin dramatically reduces the migration ability of S18 and HONE-1 cells. Nigericin exhibits gteat toxicity for the HT29 and SW116 cell line with IC 50 of 12.92±0.25 μmol and 15.86±0.18 μmol. Nigericin also shows a decreased ability to form colonies under anchorage-independent conditions in a standard soft agar assay. |
| In vivo study | Ngericin (4 mg/kg, i.p.) significantly reduces tumor growth and acts synergistically with the chemotherapeutic agent DDP, as shown by the tumor volumes. Nigericin markedly decreases Bmi-1 in vivo. Overexpression of Bmi-1 partially restores CSC content and metastatic ability of NPC cells under Nigericin treatment. The downregulation of Bmi-1 may be involved in the inhibitory effect of Nigericin on CSCs in NPC. |
Nigericin, monosodium salt - Risk and Safety
| Hazard Symbols | T - Toxic |
| Risk Codes | R25 - Toxic if swallowed R36/37/38 - Irritating to eyes, respiratory system and skin. |
| Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. S45 - In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.) |
| UN IDs | UN 3462 6.1/PG 3 |
| WGK Germany | 3 |
| RTECS | QT6840000 |
| HS Code | 29419090 |
| Hazard Class | 6.1 |
Nigericin, monosodium salt - Reference
| Reference Show more | 1. [IF=4.098] Xueqin Jiang et al."A mitochondria-targeted two-photon fluorescent probe for sensing and imaging pH changes in living cells."Spectrochim Acta A. 2020 Jan;224:117435 |
Nigericin, monosodium salt - Reference Information
| biological activity | the sodium salt of Nigericin is an antibiotic derived from Streptomyces hydroscopicus by acting as H, the ionophore of K and Pb2 functions. Nigericin can activate NLRP3 inflammasomes to induce pro-inflammatory and immunostimulatory processes. |
| Target | Value |
Last Update：2024-04-09 20:45:29
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Product Name: Nigericin Sodium Salt Request for quotation
CAS: 28643-80-3
Tel: 0714-3999186
Email: 2853786052@qq.com
Mobile: 86+15671228036
QQ: 2853786052
Wechat: 15671228036
CAS: 28643-80-3
Tel: 0714-3999186
Email: 2853786052@qq.com
Mobile: 86+15671228036
QQ: 2853786052
Wechat: 15671228036
Multiple SpecificationsSpot supply
Product Name: Nigericin sodium salt Visit Supplier Webpage Request for quotationCAS: 28643-80-3
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
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